It is well-known that pharmaceutical analysis relies heavily on liquid chromatography (LC). Unfortunately, direct LC analysis of PGL faces some challenges, including a lack of chromophores, interference with excipients that absorb at similar wavelengths, and instability due to oxidative degradation (Mutalabisin et al., 2021; Kritikos et al., 2022). As a result, identification and quantification of PGL are considered a hurdle during initial routine procedures for laboratory screening.
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- PGL concentrations above the recommended range suggest that the powder samples likely contain other substances.
- No use, distribution or reproduction is permitted which does not comply with these terms.
- Moreover, the appearance of other materials, such as paracetamol (Figure 8) in some capsules, indicates unsatisfactory manufacturing practices that do not meet specified quality standards.
- Unfortunately, direct LC analysis of PGL faces some challenges, including a lack of chromophores, interference with excipients that absorb at similar wavelengths, and instability due to oxidative degradation (Mutalabisin et al., 2021; Kritikos et al., 2022).
This was achieved through optimized parameters, including lowering the flow rate (from 1.0 to 0.5 mL/min) and decreasing the injection volume (from 20 to 3 μL), while doubling sample throughput from 2 to 4 samples per hour compared to lyrica 75 mg price in canada HPLC. Bold values indicate the seized capsule samples that did not satisfy the acceptable quality standard. The forensic samples examined in the current study were seized by the General Directorate of Narcotics Control (GDNC), Saudi Arabia. The seized samples consisted of 35 capsules and 5 powder forms suspected to contain PGL. The capsules varied in shape, colour, and form, while the powders were likely intended for clandestine capsule production (Figure 2).